Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease
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Effects of Pravastatin in Adriamycin-Induced Nephropathy in Rats
The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus pravastatin (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 aft...
متن کاملEffects of Pravastatin in Adriamycin-Induced Nephropathy in Rats
The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus pravastatin (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 aft...
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The role of podocytes in the development and progression of glomerular disease has been extensively investigated in the past decade. However, the importance of glomerular endothelial cells in the pathogenesis of proteinuria and glomerulosclerosis has been largely ignored. Recent studies have demonstrated that endothelial nitric oxide synthatase (eNOS) deficiency exacerbates renal injury in anti...
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This study examines the clinical features, pathologic findings, and outcome of 24 patients with biopsy-proven lithium toxicity. The patient population was 50% male, 87.5% Caucasian, and had a mean age of 42.5 yr (range, 26 to 57). Mean duration of lithium therapy for bipolar disorder was 13.6 yr (range, 2 to 25). All patients were biopsied for renal insufficiency (mean serum creatinine 2.8 mg/d...
متن کاملCALL FOR PAPERS Chronic Kidney Disease and Fibrosis Nitro-oleic acid protects against adriamycin-induced nephropathy in mice
Shanshan Liu, Zhanjun Jia, Li Zhou, Ying Liu, Hong Ling, Shu-Feng Zhou, Aihua Zhang, Yaomin Du, Guangju Guan,* and Tianxin Yang* Department of Internal Medicine, University of Utah, Salt Lake City, Utah; Veterans Affairs Medical Center, Salt Lake City, Utah; Department of Nephrology, 2nd Affiliated Hospital, Shandong University, Jinan, China; Institute of Hypertension, Sun Yat-Sen University Sc...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1986
ISSN: 0085-2538
DOI: 10.1038/ki.1986.28